Research projects & publications

Dr Ceecee Britten-Jones’ main research focus is on improving the diagnosis of inherited retinal diseases, which are rare genetic conditions that cause irreversible vision loss. She has also undertaken research in anterior eye diseases, diabetic neuropathy, systematic reviews and meta-analyses, and ocular nutrition.

You can view a full list of Dr Alexis Ceecee Britten-Jones’ peer-reviewed publications via the links below:

Note: Dr Alexis Ceecee Britten-Jones formerly published as Alexis Ceecee Zhang

Inherited retinal diseases and ocular genetics

Investigating the progression of inherited retinal diseases and developing novel outcome measures

Dr Britten-Jones is a co-leading a research genome sequencing study developing a comprehensive patient dataset of inherited retinal diseases, along with A/Prof Lauren Ayton. This project aims to identify new genetic changes associated with inherited retinal diseases, providing new information to support the research and development of future therapies.

Selected related peer-reviewed publications

Dr Britten-Jones is focussed on driving the genetic sequencing components of this project, and her specific interest is understanding clinical characteristics associated with different DNA variants.

Identifying novel variants associated with inherited retinal diseases

Dr Britten-Jones is an investigator on the Victorian evolution of inherited retinal diseases (IRD) natural history registry (VENTURE), an Australian IRD registry that collects genotype and phenotype data to learn more about different IRDs. VENTURE is a collaborative project, co-led by A/Prof Lauren Ayton and Dr Thomas Edwards at the University of Melbourne and Centre for Eye Research Australia.

In this study, the team is also working on developing novel outcome measures for emerging gene and cell therapy clinical trials.

Selected related peer-reviewed publications

Understanding patient perspectives and improving diagnostic support for people with vision loss

This research project aims to identify ways to support people with inherited retinal diseases during their diagnosis, such as genetic counselling and low vision support. This project also includes improving the knowledge of primary eyecare clinicians on the diagnosis and management of IRDs.

Selected peer-reviewed publications – Patient perspectives

Selected peer-reviewed publications – Clinician education

Other research projects

Systematic reviews and meta-analyses

Dr Britten-Jones has led and contributed to a number of systematic reviews, including Cochrane reviews. She has expertise in the methods used to synthesise evidence, both quantitative (meta-analyses) and qualitative (synthesis without meta-analysis).

Anterior eye health and dry eye disease

Dr Britten-Jones was a member of the Tear Film and Ocular Surface Society (TFOS) global workshop: A Lifestyle Epidemic, and has contributed to a number of works on improving the diagnosis and management of ocular surface diseases.

Ocular nutrition and corneal neuropathy in diabetes

Dr Britten-Jones’ PhD research was on the role of omega-3 polyunsaturated fatty acids in modulating peripheral nerve health in type 1 diabetes, using corneal nerve health as a surrogate marker.